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4935 Dextromethadone
3a6aee6974f597a72ed6f57fe537c9b9873cfbabf7ba9c4cca8e2d7b2f411fb3

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Properties

Chemistry

Dextromethadone (developmental code name REL-1017) is the (S)-enantiomer of methadone. It acts as an N-methyl-D-aspartate receptor (NMDAR) antagonist. Unlike levomethadone, it has low affinity for opioid receptors and lacks significant respiratory depressant action and abuse liability. Dextromethadone is under development for the treatment of major depressive disorder. There is an asymmetric synthesis available to prepare both dextromethadone (S-(+)-methadone) and levomethadone (R-(−)-methadone).

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