Minted: - / 5000

559 Homoquinolinic acid
803a1d6fdec16df820a581cbccd2351a8da118cbee0c1d1773029bfadb627048

Properties

Background

Orange
Bottle

Green
Cap

Blue
Syringe

Light blue
Bubbles
No
Drops
No
Label
Drop

Chemistry

Formula
C8H7NO4
Carbon
8
Polarity
Neutral

Homoquinolinic acid (HQA) is a potent excitotoxin which is a conformationally-restricted analogue of N-methyl-D-aspartate (NMDA) and a partial agonist of the main/glutamate site of the NMDA receptor, with some selectivity for NR2B subunit-containing receptors. It is approximately equipotent to NMDA and about five times more potent than quinolinic acid as an agonist of the NMDA receptor. HQA has also been found to label a novel, yet uncharacterized binding site, which can be distinguished from the NMDA receptor with the use of 2-carboxy-3-carboxymethylquinoline (CCMQ), a selective ligand of the uncharacterized site.

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