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575 Idarubicin
70dc0e96a1d8a6a4f75062c9c8cf587c5fe72888cfecf30a46c7fe37fe8a1018

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Properties

Chemistry

Idarubicin or 4-demethoxydaunorubicin is an anthracycline antileukemic drug. It inserts itself into DNA and prevents DNA unwinding by interfering with the enzyme topoisomerase II. It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular uptake. Similar to other anthracyclines, it also induces histone eviction from chromatin.

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