Miraculous Medicines

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58 Tenidap
68451a89ab9befb474b989421fddad72a96f5d0f3929af80b34db613ed46d9b2

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Properties

Chemistry

Tenidap was a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory drug candidate that was under development by Pfizer as a promising potential treatment for rheumatoid arthritis, but Pfizer halted development after marketing approval was rejected by the FDA in 1996 due to liver and kidney toxicity, which was attributed to metabolites of the drug with a thiophene moiety that caused oxidative damage.

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