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68 Glufimet
6b3a4162ae7d8619a94cdfed7e48fd41a1ff587434ebb2aae94417800a97be84

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Properties

Chemistry

Glufimet (developmental code name RGPU-238), also known as dimethyl 3-phenylglutamate hydrochloride, is a derivative of glutamic acid (glutamate) which was developed in Russia and is related to the γ-aminobutyric acid (GABA) derivative phenibut (3-phenyl-GABA). It contains phenibut and glycine fragments in its chemical structure, has been described as a "GABA precursor", and is said to modulate the GABA and nitric oxide (NO) systems and to have antioxidant activity. It has been suggested that metabotropic glutamate receptors may also play a role in the mechanism of action of glufimet. Stress-protective effects have been described for glufimet in animals.

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