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730 Methaniazide
292dcf39e8724f107cd97ad9551bc6872b14fa1c9b1e7138c3f551db4828bdde

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Properties

Chemistry

Methaniazide, brand name Neotizide among others, is an antibiotic which is used in the treatment of tuberculosis. It is a derivative of methanesulfonic acid and isoniazid, which is also an antituberculosis drug but has comparatively been far more widely known and used. Isoniazid is a prodrug of isonicotinic acid, and acetylisoniazid, a metabolite of isoniazid, is a metabolic intermediate through which most of the isonicotinic acid is formed. Methaniazide features its mesylate group at the same position as that of the acetyl group in acetylisoniazid, and so methaniazide probably acts as a prodrug of isonicotinic acid similarly to isoniazid and acetylisoniazid. Methaniazide is used as the sodium salt.

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