Miraculous Medicines

teleport me to a random drug
Minted: - / 5000

759 Salicylmethylecgonine
c4b26bbbf91ac4a6bcf5e06570c810b40612a694ca9c67a727722e80a269db35

This DRUG has not been minted yet.
Mint it now with MetaMask!

Send:
ETH
and donate to medical research.
Note: transaction fees shown in metamask are an approximation and are likely to be smaller.

Properties

Chemistry

Salicylmethylecgonine, (2′-Hydroxycocaine) is a tropane derivative drug which is both a synthetic analogue and a possible active metabolite of cocaine. Its potency in vitro is around 10x that of cocaine, although it is only around three times more potent than cocaine when administered to mice (likely owing to it having a higher LogP: 2.89 than that of cocaine: 2.62) Note however that the compound 2′-Acetoxycocaine would act as a prodrug to Salicylmethylecgonine in humans, and has a more efficient partition coefficient which would act as a delivery system and would circumvent this reason for a loss in potency. Salicylmethylecgonine also shows increased behavioral stimulation compared to cocaine similar to the phenyltropanes. The hydroxy branch renders the molecule a QSAR of a 10-fold increase over cocaine in its binding potency for the dopamine transporter & a 52-fold enhanced affinity for the norepinephrine transporter. It also has a reduced selectivity for the serotonin transporter though only due to its greater increase at NET binding; its SERT affinity being 4-fold increased compared to cocaine. However, in overall binding affinity (not uptake inhibition) it displaces ligands better across the board than cocaine in all monoamine categories.

From Wikipedia, the free encyclopedia. License: CC BY-SA.
≪ Previous
758 Next ≫
760
Made with on Earth by F. Boffa and T. Calemme
This website does not track you.
Read the contract on Etherscan