Minted: - / 5000

795 Estradiol cyclooctyl acetate
bc5770551e749d0c5e197ae9f3b29e77f768d80685f4041a296f41afb3720aea

Properties

Background

Purple
Bottle

Gray
Cap

Green
Syringe

Yellow
Bubbles
No
Drops
No
Label
Drop

Chemistry

Formula
C28H40O3
Carbon
28
Polarity
Neutral

Estradiol cyclooctyl acetate (E₂COA), or estradiol 17β-cyclooctylacetate, also known as estra-1,3,5(10)-triene-3,17β-diol 17β-cyclooctylacetate, is an estrogen medication and an estrogen ester – specifically, the 17β-cyclooctyl acetate ester of estradiol – which has been studied for use in hormone replacement therapy for ovariectomized women and as a hormonal contraceptive in combination with a progestin but was never marketed. It has greater oral bioavailability than does micronized estradiol due to absorption via the lymphatic system and hence partial bypassing of first-pass metabolism. It is approximately twice as potent as micronized estradiol orally and has a comparatively reduced impact on liver parameters such as changes in sex hormone-binding globulin production. It was investigated in combination with desogestrel as a birth control pill, but resulted in unacceptable menstrual bleeding patterns and was not further developed.

From Wikipedia, the free encyclopedia. License: CC BY-SA.