Minted: - / 5000

925 Cyclotraxin B
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Properties

Background

Orange
Bottle

Orange
Cap

Light green
Syringe

Yellow
Bubbles
No
Drops
No
Label
Pill

Chemistry

Formula
C48H73N13O17S3
Carbon
48
Polarity
Neutral

Cyclotraxin B (CTX-B) is a small (1200 Da) cyclic peptide and highly potent, selective, non-competitive antagonist or negative allosteric modulator of TrkB (IC₅₀ = 0.30 nM), the main receptor of brain-derived neurotrophic factor (BDNF), which itself was derived from BDNF. It crosses the blood-brain-barrier with systemic administration and produces anxiolytic-like effects in animals, though notably not antidepressant-like effects. The compound has also been found to produce analgesic effects in animal models of neuropathic pain. In addition to TrkB, CTX-B has been found to be an allosteric modulator of VEGFR2, one of the receptors of vascular endothelial growth factor (VEGF).

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