Minted: - / 5000

1665 Propylnorapomorphine
0cfdd689b055b1e89ae57ebc2c356effdeedaadc21eb6be47eb06e66d6c45115

Properties

Background

Purple
Bottle

Orange
Cap

Green
Syringe

Light blue
Bubbles
No
Drops
No
Label
-

Chemistry

Formula
C19H21NO2
Carbon
19
Polarity
Neutral

N-n-Propylnorapomorphine (NPA) is an aporphine derivative dopamine agonist closely related to apomorphine. In rodents it has been shown to produce hyperactivity, stereotypy, hypothermia, antinociception, and penile erection, among other effects. Notably, its effects on locomotion are biphasic, with low doses producing inhibition and catalepsy and high doses resulting in enhancement of activity. This is likely due to preferential activation of D₂/D₃ autoreceptors versus postsynaptic receptors, the latter of which overcomes the former to increase postsynaptic dopaminergic signaling only with high doses.

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