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2764 Ritalinic acid
866dc9ad7f4c8904401279d348690fe4ad773170627c6864f4b1d5f5d1d25f49

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Properties

Chemistry

Ritalinic acid is a substituted phenethylamine and an inactive major metabolite of the psychostimulant drugs methylphenidate and ethylphenidate. It is also the namesake from which the common brand name for Methylphenidate, Ritalin was derived. When administered orally, methylphenidate is extensively metabolized in the liver by hydrolysis of the ester group yielding ritalinic acid. The hydrolysis was found to be catalyzed by carboxylesterase 1 (CES1).

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