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3987 Desmethylchlorotrianisene
1af58a8bd4f57d684f20f814b597d22e9cb43979afd02e3d1f06eab6575a3744

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Properties

Chemistry

Desmethylchlorotrianisene (DMCTA) is a nonsteroidal estrogen which is thought to be the major active metabolite of chlorotrianisene (CTA; TACE). It is a 1:1 mixture of cis and trans isomers. DMCTA is produced from CTA via mono-O-demethylation catalyzed by cytochrome P450 enzymes in the liver. CTA is thought to act as a long-lasting prodrug of DMCTA.

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