Minted: - / 5000

3988 Piperoxan
124b3802e87f60c6d032342b17be8317cc1afcd785a1df1cf130352704ec6495

Properties

Background

Gray
Bottle

Red
Cap

Green
Syringe

Yellow
Bubbles
No
Drops
No
Label
-

Chemistry

Formula
C14H19NO2
Carbon
14
Polarity
Neutral

Piperoxan, also known as benodaine, is a drug which was the first antihistamine to be discovered. This compound, derived from benzodioxan, was prepared in the early 1930s by Daniel Bovet and Ernest Fourneau at the Pasteur Institute in France. Formerly investigated by Fourneau as an α-adrenergic-blocking agent, they demonstrated that it also antagonized histamine-induced bronchospasm in guinea pigs, and published their findings in 1933. Bovet went on to win the 1957 Nobel Prize in Physiology or Medicine for his contribution, and one of their students, Anne-Marie Staub, published the first structure-activity relationship (SAR) study of antihistamines in 1939.

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