Minted: - / 5000

4952 Pyoluteorin
4735bf049922665e642eed6be82fe23014de35362490b9b436ad1288ced5dbf9

Properties

Background

Brown
Bottle

Light green
Cap

Orange
Syringe

Light blue
Bubbles
No
Drops
No
Label
-

Chemistry

Formula
C11H7Cl2NO3
Carbon
11
Polarity
Neutral

Pyoluteorin is a natural antibiotic that is biosynthesized from a hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) pathway. Pyoluteorin was first isolated in the 1950s from Pseudomonas aeruginosa strains T359 and IFO 3455 and was found to be toxic against oomycetes, bacteria, fungi, and against certain plants. Pyoluteorin is most notable for its toxicity against the oomycete Pythium ultimum, which is a plant pathogen that causes a global loss in agriculture. Currently, pyoluteorin derivatives are being studied as an Mcl-1 antagonist in order to target cancers that have elevated Mcl-1 levels.

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