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809 Trodusquemine
583d6061fae1e913e1f4bf5ad3b28ab5a3e371ccd713c726379fc2435d67a58c

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Properties

Chemistry

Trodusquemine is an aminosterol (a polyamine-steroid) similar to squalamine that is an allosteric inhibitor of protein-tyrosine phosphatase 1B (PTP1B). It was isolated from the dogfish shark by scientists at Magainin Pharmaceuticals (subsequently called Genaera) in 2000 and underwent some drug development as a potential treatment for diabetes or obesity, but the company ran out of money and closed in 2009.

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