Minted: - / 5000

810 Cyclorphan
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Properties

Background

Orange
Bottle

Green
Cap

Orange
Syringe

Green
Bubbles
No
Drops
No
Label
-

Chemistry

Formula
C20H27NO
Carbon
20
Polarity
Neutral

Cyclorphan is an opioid analgesic of the morphinan family that was never marketed. It acts as a μ-opioid receptor (MOR) weak partial agonist or antagonist, κ-opioid receptor (KOR) full agonist, and, to a much lesser extent, δ-opioid receptor (DOR) agonist (75-fold lower affinity relative to the KOR). The drug was first synthesized in 1964 by scientists at Research Corporation. In clinical trials, it had relatively long duration, good absorption, and provided strong pain relief but produced psychotomimetic effects via KOR activation, so its development was not continued.

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